InterPro domain: IPR004871

General Information

  • Identifier IPR004871
  • Description Cleavage/polyadenylation specificity factor, A subunit, C-terminal
  • Number of genes 557
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003676   GO:0005634  

Abstract

This family includes a region that lies towards the C terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs [ 1 ]. The function of the aligned region is unknown but may be involved in RNA/DNA binding.


1. The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA 7, 920-31

Species distribution

Gene table