InterPro domain: IPR004860
General Information
- Identifier IPR004860
- Description Homing endonuclease, LAGLIDADG
- Number of genes 117
- Gene duplication stats Loading...
- Associated GO terms GO:0004519
Abstract
Homing endonucleases (HEnases) form a large and highly diverse class of proteinsencoded by introns and inteins that confer mobility to their host genetic elements. LAGLIDADG HEnases are structured into two tandemly repeated homing endonuclease-like domains [ 1 , 2 ]. This entry represents the homing endonuclease LAGLIDADG domain [ 3 ].
1. Bacterial DUF199/COG1481 proteins including sporulation regulator WhiA are distant homologs of LAGLIDADG homing endonucleases that retained only DNA binding. Cell Cycle 6, 1666-70
2. Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure. Nucleic Acids Res. 24, 3982-9
3. Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family. Nucleic Acids Res. 25, 4626-38