InterPro domain: IPR004843

General Information

  • Identifier IPR004843
  • Description Calcineurin-like phosphoesterase domain, ApaH type
  • Number of genes 7086
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016787  

Abstract

This domain is found in a diverse range of phosphoesterases [ 1 ], including bis(5'-nucleosyl)-tetraphosphatase (apaH), nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or archaeal/yeast Mre11. The most conserved regions in this domain centre around the metal chelating residues.


1. Phosphoesterase domains associated with DNA polymerases of diverse origins. Nucleic Acids Res. 26, 3746-52

Species distribution

Gene table