InterPro domain: IPR004841
General Information
- Identifier IPR004841
- Description Amino acid permease/ SLC12A domain
- Number of genes 217
- Gene duplication stats Loading...
- Associated GO terms GO:0055085 GO:0016020
Abstract
Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ 1 ], [ 2 ], [ 3 ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second transmembrane segment.
This domain is found in amino acid permeases, as well as in solute carrier family 12A (SLC12A) members.
1. Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae. J. Mol. Evol. 27, 341-50
2. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Gene 83, 153-9
3. Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Protein Sci. 2, 20-30