InterPro domain: IPR004800
General Information
- Identifier IPR004800
- Description Phosphosugar isomerase, KdsD/KpsF-type
- Number of genes 130
- Gene duplication stats Loading...
- Associated GO terms GO:0005975 GO:0016853
Abstract
This is a family of closely related proteins with the phosphosugar-binding domain SIS (Sugar ISomerase) followed by two copies of the CBS (named after Cystathionine Beta Synthase) domain. The group includes GutQ, a protein of the glucitol operon [ 1 , 2 ] and KpsF, a virulence factor involved in capsular polysialic acid biosynthesis in some pathogenic strains of Escherichia coli [ 3 ].
1. Identification of GutQ from Escherichia coli as a D-arabinose 5-phosphate isomerase. J. Bacteriol. 187, 6936-42
2. Nucleotide sequence and expression of the gutQ gene within the glucitol operon of Escherichia coli. DNA Seq. 1, 141-5
3. Characterization of Escherichia coli D-arabinose 5-phosphate isomerase encoded by kpsF: implications for group 2 capsule biosynthesis. Biochem. J. 395, 427-32