InterPro domain: IPR004739

This signature represents the type 1 glutamine amidotransferase (GATase1) domain found in the N-terminal region of GMP synthase 6.3.5.2 . GMP synthase catalyzes the synthesis of GMP from XMP [ 1 ], [ 2 ]. ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate

GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. It belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site [ 3 ].

Glutamine amidotransferase (GATase) activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate.

1. Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain. J. Biol. Chem. 259, 9790-8
2. Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain. J. Bacteriol. 169, 3023-8
3. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat. Struct. Biol. 3, 74-86