InterPro domain: IPR004732
General Information
- Identifier IPR004732
- Description Transaldolase type 2
- Number of genes 146
- Gene duplication stats Loading...
- Associated GO terms GO:0004801 GO:0006098 GO:0005737
Abstract
Transaldolase ( 2.2.1.2 ) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated [ 1 ] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.
This entry represents transaldolases type 2, which is found in bacteria and plants.
1. Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Yeast 9, 1241-9