InterPro domain: IPR004712
General Information
- Identifier IPR004712
- Description Na+/H+ antiporter, fungi
- Number of genes 2
- Gene duplication stats Loading...
- Associated GO terms GO:0015385 GO:0016021 GO:0030004 GO:0005886
Abstract
This entry represents a group of fungal Na+/H+ antiporters, including Nha1 from budding yeasts and Sod2 (SPAC977.10) from fission yeasts. Nha1 is involved in sodium and potassium efflux through the plasma membrane. It plays a role in the homeostatic regulation of the plasma membrane potential [ 1 ]. Sod2 is a Na+/H+ exchanger that is responsible for salt tolerance [ 2 ]. The structure of Sod2 has been revealed [ 3 ].
1. The Na+,K+/H+ -antiporter Nha1 influences the plasma membrane potential of Saccharomyces cerevisiae. FEMS Yeast Res. 6, 792-800
2. Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe. Biochim. Biophys. Acta 1788, 983-92
3. Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2. J. Biol. Chem. 288, 24609-24