InterPro domain: IPR004653

General Information

  • Identifier IPR004653
  • Description tRNA-dihydrouridine(20/20a) synthase
  • Number of genes 171
  • Gene duplication stats Loading...
  • Associated GO terms GO:0017150   GO:0002943  

Abstract

This entry represents dusA (also known as tRNA-dihydrouridine(20/20a) synthase), which specifically modifies U20 and U20a in tRNAs [ 1 ].

Dihydrouridine (D) is a highly conserved modified base found in tRNAs from all domains of life. D is formed by reduction of the carbon-carbon double bond at positions 5 and 6 of the uridine base by dihydrouridine synthases (Dus), and is mostly found in the D-loop of tRNAs for which it is named [ 2 ].


1. Molecular basis of dihydrouridine formation on tRNA. Proc. Natl. Acad. Sci. U.S.A. 108, 19593-8

Species distribution

Gene table