InterPro domain: IPR004598
General Information
- Identifier IPR004598
- Description Transcription factor TFIIH subunit p52/Tfb2
- Number of genes 140
- Gene duplication stats Loading...
- Associated GO terms GO:0000439 GO:0006289 GO:0001671
Abstract
This entry represents the p52/Tfb2 subunit in the TFIIH complex, which is not only required for transcription but also plays a central role in DNA repair. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT1, cyclin H and Cdk7) [ 1 , 2 , 3 ]. The p52 subunit interacts with subunit XPB, which is an ATP-dependent 3'-5' DNA helicase, and stimulates its ATPase activity [ 4 ].
1. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst.) 10, 714-21
2. Subunit architecture of general transcription factor TFIIH. Proc. Natl. Acad. Sci. U.S.A. 109, 1949-54
3. TFIIH: when transcription met DNA repair. Nat. Rev. Mol. Cell Biol. 13, 343-54
4. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26, 245-56