InterPro domain: IPR004595

General Information

  • Identifier IPR004595
  • Description TFIIH C1-like domain
  • Number of genes 108
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006281   GO:0008270  

Abstract

The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domains. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C [ 1 ].


1. Structural characterization of the cysteine-rich domain of TFIIH p44 subunit. J. Biol. Chem. 275, 31963-71

Species distribution

Gene table