InterPro domain: IPR004588

General Information

  • Identifier IPR004588
  • Description 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type
  • Number of genes 156
  • Gene duplication stats Loading...
  • Associated GO terms GO:0046429   GO:0016114  

Abstract

This protein previously of unknown biochemical function is essential in Escherichia coli. It has now been characterised as 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step of nonmevalonate terpenoid biosynthesis. The family is largely restricted to bacteria, where it is widely but not universally distributed. No homology can be detected between this family and other proteins.

Species distribution

Gene table