InterPro domain: IPR004580

General Information

  • Identifier IPR004580
  • Description DNA repair protein Rad18, fungi

Abstract

During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeast Saccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The Rad18 gene encodes a RING-finger protein with single-stranded DNA binding activity that interacts with the ubiquitin-conjugating enzyme Rad6.

This entry represents the Rad8 from fungi.

Species distribution

Gene table