InterPro domain: IPR004538
General Information
- Identifier IPR004538
- Description Haemolysin A /rRNA methyltransferase TlyA
- Number of genes 118
- Gene duplication stats Loading...
- Associated GO terms GO:0003723
Abstract
Haemolysins are exotoxins that attack blood cell membranes and cause cell rupture. The mechanism of action is not well defined. Haemolysin A is induced by sodium ribonucleate, and is produced by pathogenic bacterial strains. Haemolysin A from Treponema hyodysenteriae causes swine dysentery [ 1 ]. The homologous protein from Mycobacterium tuberculosis is known as 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA and exhibits hemolytic activity in vitro. It catalyses the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA [ 2 , 3 , 4 ].
1. Cloning and expression of a Serpula (Treponema) hyodysenteriae hemolysin gene. Infect. Immun. 60, 529-35
2. Characterization of a haemolysin from Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae. Microbiology (Reading, Engl.) 144 ( Pt 5), 1205-11
3. Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase. BMC Biochem. 11, 35
4. Molecular modeling and in silico characterization of Mycobacterium tuberculosis TlyA: possible misannotation of this tubercle bacilli-hemolysin. BMC Struct. Biol. 11, 16