InterPro domain: IPR004520

General Information

  • Identifier IPR004520
  • Description tRNA modification GTPase MnmE

Abstract

MnmE, also called TrmE and previously designated ThdF (thiophene and furan oxidation protein), is a GTPase involved in tRNA modification to create 5-methylaminomethyl-2-thiouridine in the wobble position of some tRNAs [ 1 ]. This protein and GidA form an alpha2/beta2 heterotetramer.


1. The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. EMBO J. 18, 7063-76

Species distribution

Gene table