InterPro domain: IPR004511

This entry represents a family of phosphoadenosine phosphosulphate (PAPS) reductases and adenosine 5'-phosphosulphate (APS) reductases involved in the assimilatory reduction of inorganic sulphate. The APS reductases can be distinguished from the PAPS reductases by the presence of two additional cysteine pairs thought to form an iron-sulphur cluster [ 1 ].

1. The presence of an iron-sulfur cluster in adenosine 5'-phosphosulfate reductase separates organisms utilizing adenosine 5'-phosphosulfate and phosphoadenosine 5'-phosphosulfate for sulfate assimilation. J. Biol. Chem. 277, 21786-91