InterPro domain: IPR004508

General Information

  • Identifier IPR004508
  • Description Thioredoxin-independent 5'-adenylylsulphate reductase
  • Number of genes 213
  • Gene duplication stats Loading...
  • Associated GO terms GO:0019419   GO:0016671  

Abstract

This enzyme, involved in the assimilation of inorganic sulphate, is closely related to the thioredoxin-dependent PAPS reductase of Bacteria (CysH) and Saccharomyces cerevisiae. However, it has its own C-terminal thioredoxin-like domain and is not thioredoxin-dependent. Also, it has a substrate preference for 5'-adenylylsulphate (APS) over 3'-phosphoadenylylsulphate (PAPS) so the pathway does not require an APS kinase (CysC) to convert APS to PAPS. Arabidopsis thaliana appears to have three isozymes, all able to complement Escherichia coli CysH mutants (even in backgrounds lacking thioredoxin or APS kinase) but likely localized to different compartments in Arabidopsis.

Species distribution

Gene table

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