InterPro domain: IPR004506

General Information

  • Identifier IPR004506
  • Description tRNA-specific 2-thiouridylase
  • Number of genes 126
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008033   GO:0016740  

Abstract

This family represents tRNA-specific 2-thiouridylase (sometimes called tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase), which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine (mnm5s2U) present in the wobble position of some tRNAs [ 1 ]. This family of enzyme only presents in bacteria and eukaryote. The archaeal counterpart of this enzyme performs same function, but is completely unrelated in sequence [ 2 ].


1. Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities. J. Biol. Chem. 262, 8488-95
2. Distinct origins of tRNA(m1G37) methyltransferase. J. Mol. Biol. 339, 707-19

Species distribution

Gene table