InterPro domain: IPR004504
General Information
- Identifier IPR004504
- Description DNA repair protein RadA
- Number of genes 89
- Gene duplication stats Loading...
- Associated GO terms GO:0005524 GO:0006281 GO:0003684
Abstract
RadA/Sms is a highly conserved eubacterial protein that shares sequence similarity with both RecA strand transferase and lon protease. The RadA/Sms family are probable ATP-dependent proteases involved in both DNA repair and degradation of proteins, peptides, glycopeptides. They are classified in as non-peptidase homologues and unassigned peptidases in MEROPS peptidase family S16 (lon protease family, clan SJ).
RadA/Sms is involved in recombination and recombinational repair, most likely involving the stabilisation or processing of branched DNA molecules or blocked replication forks because of its genetic redundancy with RecG and RuvABC [ 1 ].
1. Role for radA/sms in recombination intermediate processing in Escherichia coli. J. Bacteriol. 184, 6836-44