InterPro domain: IPR004472
General Information
- Identifier IPR004472
- Description Dethiobiotin synthase BioD
- Number of genes 3
- Gene duplication stats Loading...
- Associated GO terms GO:0000287 GO:0005524 GO:0004141 GO:0009102
Abstract
BioD is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP) [ 1 ]. It binds ATP and requires magnesium as a co-factor.
Proteins in this entry also include bifunctional proteins, such as BioCD from Bordetella avium, BioDA from Aspergillus nidulans [ 2 ], and BIO3-BIO1 protein from plants. They are also involved in the biotin biosynthesis [ 3 ].
1. The purification and properties of dethiobiotin synthetase. J. Biol. Chem. 245, 6558-66
2. Characterization of the Aspergillus nidulans biotin biosynthetic gene cluster and use of the bioDA gene as a new transformation marker. Fungal Genet. Biol. 48, 208-15
3. A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Plant Physiol. 146, 60-73