InterPro domain: IPR004469

Phosphoserine phosphatase ( 3.1.3.3 ), also known as O-phosphoserine phosphohydrolase, is involved in both serine and glycine biosynthesis. It catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate, which is the last step in the biosynthesis of serine from carbohydrates. The reaction proceeds via the formation of a phosphoryl-enzyme intermediate. It acts as a homodimer, and requires magnesium as a cofactor [ 1 ].

1. High-resolution structure of human phosphoserine phosphatase in open conformation. Acta Crystallogr. D Biol. Crystallogr. 59, 971-7