InterPro domain: IPR004410

Malonyl CoA-acyl carrier protein transacylases transfer the malonyl moiety from coenzyme A to acyl-carrier protein. This entry represents the FabD-type enzymes, which include the fatty acid biosynthesis protein FabD and the antibiotic biosynthesis proteins PksC, PksE, BaeE/C and ThaF [ 1 , 2 , 3 , 4 ].

1. Cloning, nucleotide sequence, and expression of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase. J. Bacteriol. 174, 2851-7
2. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc. Natl. Acad. Sci. U.S.A. 103, 8977-82
3. Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132, 13966-8
4. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A 104, 1506-9