InterPro domain: IPR004390

FtsY is involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. It acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). In E. coli, interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components [ 1 , 2 , 3 ].

1. Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry 40, 15224-33
2. Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. J. Cell Biol. 178, 611-20
3. FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep. 6, 476-81