InterPro domain: IPR004373

General Information

  • Identifier IPR004373
  • Description Peptide chain release factor 1
  • Number of genes 171
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006415   GO:0016149  

Abstract

This entry represents peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognise and terminate translation at UAA and UAG stop codons [ 1 ]. This entry also includes chloroplast release factor APG3, which is an orthologue of E. coli RF1 and is essential for chloroplast development. APG3 could complement E. coli RF1 mutants, but not RF2 mutants, indicating that AP3 may function as RF1 in E. coli, showing specificity of stop codon recognition [ 2 ].


1. Release factors differing in specificity for terminator codons. Proc. Natl. Acad. Sci. U.S.A. 61, 768-74
2. Chloroplast ribosome release factor 1 (AtcpRF1) is essential for chloroplast development. Plant Mol. Biol. 64, 481-97

Species distribution

Gene table