InterPro domain: IPR004277

General Information

  • Identifier IPR004277
  • Description Phosphatidyl serine synthase
  • Number of genes 187
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006659   GO:0106245  

Abstract

Phosphatidyl serine synthase is also known as serine exchange enzyme ( 2.7.8 ). This family represents eukaryotic PSS I and II, membrane bound proteins that catalyse the replacement of the head group of a phospholipid (phosphotidylcholine or phosphotidylethanolamine) by L-serine [ 1 ].

Proteins in this entry include Pss from Drosophila melanogaster. Pss has been shown to regulate cell growth, lipid storage and mitochondrial function [ 2 ].


1. Phosphatidylserine synthase I and II of mammalian cells. Biochim. Biophys. Acta 1348, 151-6
2. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genet. 15, e1008548

Species distribution

Gene table