InterPro domain: IPR004170

The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [ 1 ]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [ 2 ].

1. Structure and Notch receptor binding of the tandem WWE domain of Deltex. Structure 13, 1599-611
2. The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation. Trends Biochem. Sci. 26, 273-5