InterPro domain: IPR004166
General Information
- Identifier IPR004166
- Description MHCK/EF2 kinase
- Number of genes 20
- Gene duplication stats Loading...
- Associated GO terms GO:0005524 GO:0004674 GO:0006468
Abstract
Proteins containing this domain consist of a novel group of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. Proteins include myosin heavy chain kinases [ 1 , 2 ] and Elongation Factor-2 kinase and a bifunctional ion channel [ 3 ].
1. Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins. J. Biol. Chem. 270, 523-9
2. Mapping of the novel protein kinase catalytic domain of Dictyostelium myosin II heavy chain kinase A. J. Biol. Chem. 272, 6846-9
3. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291, 1043-7