InterPro domain: IPR004123

This entry represents fission yeast Dim1 and its homologues, including Dib1 from budding yeasts, YLS8 from plants and TXNL4 from animals. Dim1 was originally identified as a mitosis protein [ 1 ]. Later, it was found to interact with spliceosome component Prp6, which is involved in pre-mRNA splicing [ 2 ]. Dim1 may act at the level of mRNA, which impacts the functioning of the APC/C, a critical complex in controlling mitotic progression [ 3 ].

It's worth noting that although the Dim proteins exhibit a thioredoxin-like fold, they lack the disulfide bond required for the thioredoxin redox activity [ 4 ].

1. Fission yeast dim1(+) encodes a functionally conserved polypeptide essential for mitosis. J. Cell Biol. 137, 1337-54
2. Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. Gene 257, 33-43
3. Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex. Eukaryotic Cell 4, 577-87
4. The Dim protein family: from structure to splicing. Cell. Mol. Life Sci. 64, 2079-89