InterPro domain: IPR004107

General Information

  • Identifier IPR004107
  • Description Integrase, SAM-like, N-terminal
  • Number of genes 2
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003677   GO:0015074  

Abstract

Proteins containing this domain cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment [ 1 , 2 ].

The phage integrase N-terminal SAM-like domain is almost always found with the signature that defines the phage integrase family (see IPR002104 ).


1. Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Science 276, 126-31
2. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Nature 389, 40-6

Species distribution

Gene table