InterPro domain: IPR004104
General Information
- Identifier IPR004104
- Description Gfo/Idh/MocA-like oxidoreductase, C-terminal
- Number of genes 215
- Gene duplication stats Loading...
Abstract
In general, the Gfo/Idh/MocA protein family members are enzymes that catalyse various different chemical reactions such as oxidation and reduction of carbohydrates, oxidation of trans-dihydrodiols, reduction of biliverdin, and hydrolysation of glycosidic bonds. All the enzymes in this family utilise NAD(P) as a hydride donor or acceptor. However, despite the structural similarities, some member such as the transcriptional repressor Gal80p, does not have enzymatic activity [ 1 ].
The Gfo/Idh/MocA protein family members consists of two main domains: an N-terminal dinucleotide-binding domain containing a typical Rossmann fold3 and a C-terminal alpha/beta-domain participating in substrate binding and oligomerisation. This entry represents the C-terminal domain [ 2 ].
1. Structural and functional features of the NAD(P) dependent Gfo/Idh/MocA protein family oxidoreductases. Protein Sci. 25, 778-86