InterPro domain: IPR003854

This is the GASA gibberellin regulated cysteine rich protein (GRPs) family. The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have a role in plant development and some of its members have antimicrobial activity [ 1 , 2 ]. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to possess 6 disulphide bonds.

Included in this family are some GRPs found in fruits and pollens that have been identified as allergens, including peach Pru p 7, Japanese apricot Pru m 7, orange Cit s 7, pomegranate Pun g 7, and cypress pollen GRP [ 3 , 3 , 4 ].

1. Gibberellin-regulated protein allergy: Clinical features and cross-reactivity. Allergol Int 69, 11-18
2. Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection. Plant Physiol 128, 951-61
3. Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species. Clin Exp Allergy 50, 964-972
4. Peamaclein--a new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3. Clin Exp Allergy 43, 128-40