InterPro domain: IPR003846

SelO and its homologues are widespread among most eukaryotic taxa, and are also common in many major bacterial taxa. SelO is a conserved pseudokinase that transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation). It contains a protein kinase fold with ATP flipped in the active site [ 1 ]. In eukaryotes, it is a mitochondrial protein that may be involved in redox biology [ 2 ].

1. Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell 175, 809-821.e19
2. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. PLoS ONE 9, e95518