InterPro domain: IPR003737

Members of this family include N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase ( 3.5.1.89 ) that catalyses the second step in glycosylphosphatidylinositol (GPI) biosynthesis [ 1 , 2 ] and 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase ( 3.5.1.103 ), involved in the biosynthesis of mycothiol (an unusual thiol compound found in Actinobacteria) [ 3 ].

1. Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem. J. 339 ( Pt 1), 185-92
2. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J. Biol. Chem. 278, 47166-70
3. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J. Bacteriol. 182, 6958-63