InterPro domain: IPR003734

This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts.

RMND1 and its yeast homologue, Mrx10, are mitochondrial proteins required for mitochondrial translation [ 1 , 2 ].

Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation [ 3 ].

1. An RMND1 Mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect. Am. J. Hum. Genet. 91, 737-43
2. Infantile encephaloneuromyopathy and defective mitochondrial translation are due to a homozygous RMND1 mutation. Am. J. Hum. Genet. 91, 729-36
3. Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163, 47-54