InterPro domain: IPR003709
General Information
- Identifier IPR003709
- Description Peptidase M15B
- Number of genes 3
- Gene duplication stats Loading...
- Associated GO terms GO:0006508 GO:0008233
Abstract
These proteins are metallopeptidases belonging to MEROPS peptidase family M15 (clan MD), subfamily M15B (vanY D-Ala-D-Ala carboxypeptidase).
Acquired VanA- and VanB-type glycopeptide resistance in enterococci is due to synthesis of modified peptidoglycan precursors terminating in D-lactate. As opposed to VanA-type strains which are resistant to both vancomycin and teicoplanin, VanB-type strains remain teicoplanin susceptible [ 1 ]. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase 3.4.16.4 activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides [ 2 ].
1. Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. J. Bacteriol. 178, 1302-9
2. Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147. Gene 120, 111-4