InterPro domain: IPR003567

General Information

  • Identifier IPR003567
  • Description Cytochrome c-type biogenesis protein

Abstract

Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ 1 ], CcmF [ 2 , 3 ], NrfE [ 4 ] and CcbS [ 5 ]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase. Members of the family are probably integral membrane proteins, with up to 16 predicted transmembrane (TM) helices.


1. Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum. J. Bacteriol. 177, 4927-34
2. Escherichia coli genes required for cytochrome c maturation. J. Bacteriol. 177, 4321-6
3. The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter. Microbiology (Reading, Engl.) 143 ( Pt 2), 563-76
4. A seven-gene operon essential for formate-dependent nitrite reduction to ammonia by enteric bacteria. Mol. Microbiol. 12, 153-63
5. A plant mitochondrial gene encodes a protein involved in cytochrome c biogenesis. Mol. Gen. Genet. 239, 49-57

Species distribution

Gene table