InterPro domain: IPR003453

This entry represents a subfamily of ABC transporter permease subunits. In Q7DD59 it is involved in L-glutamate import into the cell [ 1 ]. In Q8L4R0 it is involved in lipid transfer within the cell [ 2 ]. In P64606 (MlaE) it is involved in phospholipid transport as part of the Mla system, whose role is preserving outer membrane lipid asymmetry [ 3 ]. Many bacterial species have one or two members from this family. The Mycobacteria have large paralogous families included in IPR030802 , but excluded from this subfamily [ 4 , 4 ].

1. Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments. Infect. Immun. 74, 1725-40
2. A permease-like protein involved in ER to thylakoid lipid transfer in Arabidopsis. EMBO J. 22, 2370-9
3. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc. Natl. Acad. Sci. U.S.A. 106, 8009-14