InterPro domain: IPR003170
General Information
- Identifier IPR003170
- Description UDP-N-acetylenolpyruvoylglucosamine reductase
- Number of genes 55
- Gene duplication stats Loading...
- Associated GO terms GO:0008762
Abstract
Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes, which are also called UDP-N-acetylmuramate dehydrogenases. This enzyme is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis and consequently provides an attractive target for the design of antibacterial agents.
The crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase in the presence of its substrate, enolpyruvyl-UDP-N-acetylglucosamine, has been solved to 2.7 A resolution. The structure reveals a novel flavin binding motif, shows a striking alignment of the flavin with the substrate, and suggests a catalytic mechanism for the reduction of this enol ether [ 1 ].
1. An enzyme-substrate complex involved in bacterial cell wall biosynthesis. Nat. Struct. Biol. 2, 644-53