InterPro domain: IPR003115

Proteins containing this domain include Escherichia coli plasmid protein ParB and mammalian Sulfiredoxin-1.

ParB is involved in chromosome partition. It localize to both poles of the predivisional cell following completion of DNA replication [ 1 ].

Sulfiredoxin-1 contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 [ 2 ].

1. Productive interaction between the chromosome partitioning proteins, ParA and ParB, is required for the progression of the cell cycle in Caulobacter crescentus. Mol. Microbiol. 47, 1225-37
2. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J. Biol. Chem. 279, 50994-1001