InterPro domain: IPR003038

Members of this family are thought to be integral membraneproteins. Some members of this family have been shown tocause apoptosis if mutated [ 1 ], these proteins are known asDAD for defender against death. The family also includesthe epsilon subunit of the oligosaccharyltransferase thatis involved in N-linked glycosylation (also known as Ost2) [ 2 ].

DAD1/Ost2 is a component of the N-oligosaccharyl transferase enzyme which catalyses the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [ 3 ].

1. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol. Cell. Biol. 13, 6367-74
2. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. J. Cell Biol. 131, 371-83
3. The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation. Genes Cells 2, 129-41