InterPro domain: IPR002818

The domain is found in intracellular cysteine peptidase PfpI [ 1 ] and other members of the DJ-1/ThiJ/PfpI superfamily [ 2 ]. Some of these have been characterised:

• Pyrococcus horikoshii PH1704, which has both aminopeptidase and endopeptidase activity [ 3 ].
• Arabidopsis thaliana DJ1D, which has glyoxalase I activity [ 4 ].
• Candida albicans glyoxalase 3 [ 5 ].

It is also found in transcriptional regulators in combination with a HTH(araC) domain, such as in Pseudomonas aeruginosa cdhR [ 6 ].

1. Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus. J. Bacteriol. 178, 2605-12
2. The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Proc. Natl. Acad. Sci. U.S.A. 101, 1531-6
3. Characterization of the PH1704 protease from Pyrococcus horikoshii OT3 and the critical functions of Tyr120. PLoS ONE 9, e103902
4. Novel glyoxalases from Arabidopsis thaliana. FEBS J. 280, 3328-39
5. A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans. J. Biol. Chem. 289, 1662-74
6. Identification of genes required for Pseudomonas aeruginosa carnitine catabolism. Microbiology (Reading, Engl.) 155, 2411-9