InterPro domain: IPR002786
General Information
- Identifier IPR002786
- Description Inosine/xanthosine triphosphatase
- Number of genes 1
- Gene duplication stats Loading...
Abstract
This is a family of prokaryotic phosphatases that hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. They probably exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions. ITP is the best substrate, followed by XTP, GDP or dITP [ 1 ].
Proteins in this entry include YjjX from E. coli. YjjX hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. However, it is not active on dATP and dGTP, and exhibits no phosphatase activity toward pyrimidines (CTP, TTP, UTP, dCTP, and dTTP) [ 2 ].
1. Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis. Structure 13, 1511-20