InterPro domain: IPR002695
General Information
- Identifier IPR002695
- Description Bifunctional purine biosynthesis protein PurH-like
- Number of genes 210
- Gene duplication stats Loading...
- Associated GO terms GO:0006164 GO:0003937 GO:0004643
Abstract
This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase 2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [ 1 ]. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase 3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [ 2 ].
1. Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Gene 197, 289-93