InterPro domain: IPR002687

The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):

• Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.
• Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
• Archaeal Nop5, an homologue of Nop56/Nop58.

The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively alpha-helical [ 1 , 2 ].

This entry represents the Nop domain.

1. Structure and function of archaeal box C/D sRNP core proteins. Nat. Struct. Biol. 10, 256-63
2. Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science 316, 115-20