InterPro domain: IPR002661

General Information

  • Identifier IPR002661
  • Description Ribosome recycling factor
  • Number of genes 250
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006412  

Abstract

The ribosome recycling factor or ribosome release factor (RRF) dissociates ribosomes from mRNA after termination of translation, and is essential for bacterial growth [ 1 ]. Thus ribosomes are 'recycled' and ready for another round of protein synthesis.

RRF is believed to bind the ribosome at the A-site in a manner that mimics tRNA, but the specific mechanisms remain unclear [ 2 ].


1. Ribosome recycling factor (ribosome releasing factor) is essential for bacterial growth. Proc. Natl. Acad. Sci. U.S.A. 91, 4249-53
2. Functional mapping of ribosome-contact sites in the ribosome recycling factor: a structural view from a tRNA mimic. RNA 7, 64-70

Species distribution

Gene table