InterPro domain: IPR002586
General Information
- Identifier IPR002586
- Description CobQ/CobB/MinD/ParA nucleotide binding domain
- Number of genes 126
- Gene duplication stats Loading...
Abstract
This domain is found in various cobyrinic acid a,c-diamide synthases. These include CbiA ( P29946 ) and CbiP ( Q05597 ) from S. typhimurium [ 1 ], and CobQ ( Q52686 ) from R. capsulatus [ 2 ]. These amidases catalyse amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria [ 3 ].
The domain is also found in dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [ 3 ].
1. Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J. Bacteriol. 175, 3303-16
2. Identification and sequence analysis of genes involved in late steps in cobalamin (vitamin B12) synthesis in Rhodobacter capsulatus. J. Bacteriol. 177, 4481-7
3. A family of ATPases involved in active partitioning of diverse bacterial plasmids. Mol. Microbiol. 4, 1455-63