InterPro domain: IPR002528

General Information

  • Identifier IPR002528
  • Description Multi antimicrobial extrusion protein

Abstract

In general, proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR) [ 1 , 2 ]. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs. MATE proteins are found in bacteria, archaea and eukaryotes. These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix [ 3 ].


1. Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev 64, 672-93
2. The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur. J. Biochem. 270, 799-813

Species distribution

Gene table