InterPro domain: IPR002524
General Information
- Identifier IPR002524
- Description Cation efflux protein
- Number of genes 1508
- Gene duplication stats Loading...
- Associated GO terms GO:0006812 GO:0055085 GO:0008324 GO:0016021
Abstract
Members of this family are integral membrane proteins, thatare found to increase tolerance to divalent metal ions suchas cadmium, zinc, and cobalt. These proteins are considered tobe efflux pumps that remove these ions from cells [ 1 , 2 ], however others are implicated in ion uptake [ 3 ]. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence.
1. Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus. J. Bacteriol. 180, 4024-9
2. Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14. Biosci. Biotechnol. Biochem. 60, 699-704
3. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 3678-88