InterPro domain: IPR002504
General Information
- Identifier IPR002504
- Description NAD kinase
- Number of genes 433
- Gene duplication stats Loading...
- Associated GO terms GO:0003951 GO:0006741
Abstract
Members of this family are NAD kinases 2.7.1.23 . The enzymes catalyse the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates, as well as inorganic polyphosphate, as a source of phosphorus. Such enzymes are thus designated poly(P)/ATP-NAD kinases [ 1 ]. NAD kinase is one of the key enzymes regulating the cellular NADP(H) level, and therefore NADPH-dependent reductive biosynthetic pathways [ 2 ].
1. Inorganic Polyphosphate/ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv. Biochem. Biophys. Res. Commun. 276, 57-63
2. The cyanobacterial NAD kinase gene sll1415 is required for photoheterotrophic growth and cellular redox homeostasis in Synechocystis sp. strain PCC 6803. J. Bacteriol. 194, 218-24