InterPro domain: IPR002496

General Information

  • Identifier IPR002496
  • Description Phosphoribosyl-AMP cyclohydrolase domain
  • Number of genes 152
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004635   GO:0000105  

Abstract

The phosphoribosyl-AMP cyclohydrolase 3.5.4.19 catalyses the third step in the histidine (his) biosynthetic pathway:

5-phosphoribosyl-AMP H 2 O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phospho-ribosyl) imidazole-4-carboxamide

It requires Zn 2 ions for activity [ 1 ].


1. N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase: purification and characterization of a unique metalloenzyme. Biochemistry 38, 1537-46

Species distribution

Gene table